InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fpr1

Summary

InnateDB Gene

IDBG-141074.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fpr1

Gene Name

formyl peptide receptor 1

Synonyms

fMLF-R; FPR; LXA4R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000045551

Encoded Proteins

IDBP-141076

formyl peptide receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25605714

[Homo sapiens] FPR1 and FPR2 are G-protein-coupled receptors that recognize bacterial signal peptides, constituting a novel class of immune activators that contribute to mammalian immune defence against bacteria.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171051:
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:17876471-17883940

Strand

Reverse strand

Band

A3.2

Transcripts

ENSMUST00000061516

ENSMUSP00000052894

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004982	N-formyl peptide receptor activity
GO:0005515	protein binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway