Version 5.4
Homo sapiens Gene: MRPL51
Summary
InnateDB Gene IDBG-14141.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL51
Gene Name mitochondrial ribosomal protein L51
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111639
Encoded Proteins
IDBP-14143
mitochondrial ribosomal protein L51
IDBP-812551
mitochondrial ribosomal protein L51
IDBP-812556
mitochondrial ribosomal protein L51
IDBP-717067
IDBP-812561
mitochondrial ribosomal protein L51
IDBP-812562
mitochondrial ribosomal protein L51
IDBP-812564
mitochondrial ribosomal protein L51
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6491886-6493841
Strand Reverse strand
Band p13.31
Transcripts
ENST00000229238 ENSP00000229238
ENST00000537701 ENSP00000480329
ENST00000543164 ENSP00000482353
ENST00000543703 ENSP00000471687
ENST00000538814 ENSP00000478132
ENST00000543959 ENSP00000477598
ENST00000540949 ENSP00000478326
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005739 mitochondrion
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030335
View Gene Order
ENSBTAG00000014729
Not yet available
Pathways
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267680
Mitochondrial translation initiation pathway
REACT_267602
Mitochondrial translation termination pathway
REACT_267677
Mitochondrial translation elongation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL M0R176
UniProt Splice Variant
Entrez Gene 51258
UniGene
RefSeq NM_016497
HUGO HGNC:14044
OMIM 611855
CCDS CCDS8547
HPRD
IMGT
EMBL AC006064
GenPept
RNA Seq Atlas 51258

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca