Version 5.4
Homo sapiens Gene: GEMIN4
Summary
InnateDB Gene IDBG-14171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GEMIN4
Gene Name gem (nuclear organelle) associated protein 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000179409
Encoded Proteins
IDBP-14173
gem (nuclear organelle) associated protein 4
IDBP-360784
gem (nuclear organelle) associated protein 4
IDBP-763363
IDBP-760989
IDBP-758489
IDBP-762441
IDBP-758143
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:744414-753999
Strand Reverse strand
Band p13.3
Transcripts
ENST00000319004 ENSP00000321706
ENST00000437269 ENSP00000392460
ENST00000570364 ENSP00000461103
ENST00000574958 ENSP00000458896
ENST00000576383 ENSP00000461368
ENST00000576778 ENSP00000459565
ENST00000573482 ENSP00000460286
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
Experimentally validated
Total 77 [view]
Protein-Protein 75 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000387 spliceosomal snRNP assembly
GO:0006364 rRNA processing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0034660 ncRNA metabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030532 small nuclear ribonucleoprotein complex
GO:0032797 SMN complex
GO:0034719 SMN-Sm protein complex
GO:0070062 extracellular vesicular exosome
GO:0097504 Gemini of coiled bodies
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049396
View Gene Order
ENSBTAG00000013393
Not yet available
Pathways
NETPATH
REACTOME
REACT_11066
snRNP Assembly pathway
REACT_11052
Metabolism of non-coding RNA pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL I3L2C7 I3L4M4
UniProt Splice Variant
Entrez Gene 50628
UniGene Hs.499620
RefSeq NM_015721 XM_005256667 XM_005256668 XM_005256670
HUGO HGNC:15717
OMIM 606969
CCDS CCDS45559
HPRD 07370
IMGT
EMBL AC087392
GenPept
RNA Seq Atlas 50628

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca