Version 5.4
Mus musculus Gene: Spry4
Summary
InnateDB Gene IDBG-141756.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spry4
Gene Name sprouty homolog 4 (Drosophila)
Synonyms A030006O18Rik; sprouty4
Species Mus musculus
Ensembl Gene ENSMUSG00000024427
Encoded Proteins
IDBP-141758
sprouty homolog 4 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187678:
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:38586268-38601268
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000025295 ENSMUSP00000025295
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0009966 regulation of signal transduction
GO:0043407 negative regulation of MAP kinase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187678
View Gene Order
ENSBTAG00000008250
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9WTP2
TrEMBL
UniProt Splice Variant
Entrez Gene 24066
UniGene Mm.412692 Mm.42038
RefSeq NM_011898
OMIM
CCDS CCDS29202
HPRD
IMGT
MGI ID MGI:1345144
MGI Symbol Spry4
EMBL AB019280 AF176906 AK037180 AK048122 BC050944 BC057005 CH466528
GenPept AAD56007 AAH50944 AAH57005 BAA77689 BAC29739 BAC33249 EDL10072
RNA Seq Atlas 24066

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca