InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zyx

Summary

InnateDB Gene

IDBG-141978.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zyx

Gene Name

zyxin

Synonyms

9530098H06Rik; R75157

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029860

Encoded Proteins

IDBP-141984

zyxin

IDBP-626938

zyxin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159840:
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:42349828-42360146

Strand

Forward strand

Band

B2.1

Transcripts

ENSMUST00000070635	ENSMUSP00000070427
ENSMUST00000164375	ENSMUSP00000126622

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007155	cell adhesion
GO:0050727	regulation of inflammatory response

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005913	cell-cell adherens junction
GO:0005925	focal adhesion

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000159840

View Gene Order

ENSBTAG00000017970

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04510

Focal adhesion pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04510

Focal adhesion pathway

INOH

PID NCI

thrombin_par1_pathway

PAR1-mediated thrombin signaling events

ilk_pathway

Integrin-linked kinase signaling

ecadherin_stabilization_pathway

Stabilization and expansion of the E-cadherin adherens junction

ecadherin_keratinocyte_pathway

E-cadherin signaling in keratinocytes

Cross-References

SwissProt

Q62523

TrEMBL

Q8CD55

UniProt Splice Variant

Entrez Gene

22793

UniGene

Mm.282303

RefSeq

NM_011777 XM_006505936 NM_001289617

OMIM

CCDS

CCDS20066

HPRD

IMGT

MGI ID

MGI:103072

MGI Symbol

Zyx

EMBL

AK031415 AK147812 CH466533 X99063 Y07711

GenPept

BAC27394 BAE28154 CAA67510 CAA68984 EDL13482

RNA Seq Atlas

22793