Version 5.4
Mus musculus Gene: Nub1
Summary
InnateDB Gene IDBG-142040.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nub1
Gene Name negative regulator of ubiquitin-like proteins 1
Synonyms 4931404D21Rik; 6330412F12Rik; BS4; NY-REN-18
Species Mus musculus
Ensembl Gene ENSMUSG00000028954
Encoded Proteins
IDBP-142042
negative regulator of ubiquitin-like proteins 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000013374:
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:24685815-24710555
Strand Forward strand
Band A3
Transcripts
ENSMUST00000068825 ENSMUSP00000070265
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034341 response to interferon-gamma
GO:0034612 response to tumor necrosis factor
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000013374
View Gene Order
ENSBTAG00000004540
Not yet available
Cross-References
SwissProt P54729
TrEMBL Q3UYM1
UniProt Splice Variant
Entrez Gene 53312
UniGene Mm.407975 Mm.5856
RefSeq NM_016736 XM_006535755 XM_006535756
OMIM
CCDS CCDS39030
HPRD
IMGT
MGI ID MGI:1889001
MGI Symbol Nub1
EMBL AF534114 AK134581 BC037451 CH466586 U27462
GenPept AAA68612 AAH37451 AAM97686 BAE22191 EDL03099
RNA Seq Atlas 53312

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca