Version 5.4
Homo sapiens Gene: POLD2
Summary
InnateDB Gene IDBG-14295.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLD2
Gene Name polymerase (DNA directed), delta 2, accessory subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000106628
Encoded Proteins
IDBP-14297
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
IDBP-294028
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
IDBP-373673
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
IDBP-373675
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
IDBP-373678
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
IDBP-373681
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
IDBP-373684
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
IDBP-373685
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
IDBP-807208
polymerase (DNA directed), delta 2, accessory subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3\' to 5\' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44114681-44124358
Strand Reverse strand
Band p13
Transcripts
ENST00000223361 ENSP00000223361
ENST00000406581 ENSP00000386105
ENST00000452185 ENSP00000395231
ENST00000436400 ENSP00000399447
ENST00000436844 ENSP00000416203
ENST00000433715 ENSP00000389816
ENST00000456038 ENSP00000397461
ENST00000418438 ENSP00000406702
ENST00000489883
ENST00000481104
ENST00000463464
ENST00000470867
ENST00000464871
ENST00000461116
ENST00000467469
ENST00000496539
ENST00000481763
ENST00000610533 ENSP00000480186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0032201 telomere maintenance via semi-conservative replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0043625 delta DNA polymerase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020471
View Gene Order
ENSBTAG00000012241
Not yet available
Pathways
NETPATH
REACTOME
REACT_7987
Polymerase switching on the C-strand of the telomere pathway
REACT_7999
Removal of the Flap Intermediate from the C-strand pathway
REACT_8027
Processive synthesis on the C-strand of the telomere pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_70
Removal of the Flap Intermediate pathway
REACT_1385
Processive synthesis on the lagging strand pathway
REACT_1792
Polymerase switching pathway
REACT_1838
Leading Strand Synthesis pathway
REACT_1993
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_378
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_2192
Removal of DNA patch containing abasic residue pathway
REACT_1128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_228145
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_1104
Base Excision Repair pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_228013
Mismatch Repair pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa03030
DNA replication pathway
hsa00230
Purine metabolism pathway
hsa03420
Nucleotide excision repair pathway
hsa03440
Homologous recombination pathway
hsa03430
Mismatch repair pathway
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.306791
RefSeq NM_001127218 NM_001256879 NM_006230 XM_006715745
HUGO
OMIM
CCDS CCDS5477 CCDS75586
HPRD 15982
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca