Version 5.4
Mus musculus Gene: Clta
Summary
InnateDB Gene IDBG-143084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clta
Gene Name clathrin, light polypeptide (Lca)
Synonyms AV026556; Lca
Species Mus musculus
Ensembl Gene ENSMUSG00000028478
Encoded Proteins
IDBP-265795
clathrin, light polypeptide (Lca)
IDBP-265797
clathrin, light polypeptide (Lca)
IDBP-265799
clathrin, light polypeptide (Lca)
IDBP-265801
clathrin, light polypeptide (Lca)
IDBP-265803
clathrin, light polypeptide (Lca)
IDBP-623754
clathrin, light polypeptide (Lca)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:44004452-44032846
Strand Forward strand
Band B1
Transcripts
ENSMUST00000107851 ENSMUSP00000103483
ENSMUST00000107849 ENSMUSP00000103481
ENSMUST00000107847 ENSMUSP00000103479
ENSMUST00000107846 ENSMUSP00000103478
ENSMUST00000107845 ENSMUSP00000103477
ENSMUST00000170241 ENSMUSP00000127344
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0032050 clathrin heavy chain binding
GO:0042277 peptide binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005905 coated pit
GO:0016020 membrane
GO:0030118 clathrin coat
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0030136 clathrin-coated vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0071439 clathrin complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04142
Lysosome pathway
mmu05016
Huntington's disease pathway
mmu04144
Endocytosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.487578
RefSeq NM_001080384 NM_001080385 NM_001080386 NM_001290470 NM_016760 XM_006537587 XM_006537588 XM_006537589 XM_006537590
OMIM
CCDS CCDS38746 CCDS38747 CCDS38748 CCDS38749 CCDS71377
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca