Version 5.4
Mus musculus Gene: Foxo1
Summary
InnateDB Gene IDBG-143370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Foxo1
Gene Name forkhead box O1
Synonyms Afxh; AI876417; FKHR; Fkhr1; Foxo1a
Species Mus musculus
Ensembl Gene ENSMUSG00000044167
Encoded Proteins
IDBP-143372
forkhead box O1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150907:
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:52268337-52350109
Strand Forward strand
Band C
Transcripts
ENSMUST00000053764 ENSMUSP00000055308
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 26 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0031625 ubiquitin protein ligase binding
GO:0043565 sequence-specific DNA binding
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007389 pattern specification process
GO:0008286 insulin receptor signaling pathway
GO:0009267 cellular response to starvation
GO:0009888 tissue development
GO:0010508 positive regulation of autophagy
GO:0031018 endocrine pancreas development
GO:0032869 cellular response to insulin stimulus
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034599 cellular response to oxidative stress
GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
GO:0042127 regulation of cell proliferation
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045732 positive regulation of protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071455 cellular response to hyperoxia
GO:0071732 cellular response to nitric oxide
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000150907
View Gene Order
ENSBTAG00000044105
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_221926
AKT-mediated inactivation of FOXO1A pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_218211
AKT phosphorylates targets in the nucleus pathway
REACT_242976
Signaling by EGFR pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_214529
Regulation of gene expression in beta cells pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_188576
Developmental Biology pathway
REACT_206286
GAB1 signalosome pathway
REACT_205507
Regulation of beta-cell development pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04910
Insulin signaling pathway pathway
mmu05215
Prostate cancer pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_12
BCR pathway
NetPath_15
IL3 pathway
NetPath_18
IL6 pathway
NetPath_19
IL-7 pathway
NetPath_22
Leptin pathway
NetPath_25
FSH pathway
REACTOME
REACT_12442
AKT phosphorylates targets in the nucleus pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_13655
AKT-mediated inactivation of FOXO1A pathway
REACT_13819
Regulation of gene expression in beta cells pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_13698
Regulation of beta-cell development pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_217956
DAP12 interactions pathway
REACT_208036
Signaling by EGFR pathway
REACT_222082
GAB1 signalosome pathway
REACT_213705
Regulation of gene expression in early pancreatic precursor cells pathway
REACT_204365
Signaling by PDGF pathway
REACT_216183
Signaling by ERBB4 pathway
REACT_206305
AKT-mediated inactivation of FOXO1A pathway
REACT_202211
AKT phosphorylates targets in the nucleus pathway
REACT_202837
Signaling by FGFR pathway
REACT_215558
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_219416
PI3K events in ERBB2 signaling pathway
REACT_213138
Immune System pathway
REACT_215895
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_226927
Regulation of gene expression in beta cells pathway
REACT_205435
Signaling by the B Cell Receptor (BCR) pathway
REACT_218958
Signaling by ERBB2 pathway
REACT_214353
Signal Transduction pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_204467
PI-3K cascade pathway
REACT_216123
Regulation of beta-cell development pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_222492
PI3K events in ERBB4 signaling pathway
REACT_206613
Downstream signaling of activated FGFR pathway
REACT_207066
Signalling by NGF pathway
REACT_221870
PI3K/AKT Signaling in Cancer pathway
REACT_224097
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_214469
Adaptive Immune System pathway
REACT_212750
Downstream signal transduction pathway
REACT_208171
PIP3 activates AKT signaling pathway
REACT_204114
Signaling by SCF-KIT pathway
REACT_216714
Innate Immune System pathway
REACT_225332
PI3K/AKT activation pathway
REACT_214988
DAP12 signaling pathway
REACT_207087
Disease pathway
REACT_203736
Signaling by FGFR in disease pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
REACT_220844
Developmental Biology pathway
KEGG
hsa04910
Insulin signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
foxopathway
FoxO family signaling
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
ar_tf_pathway
Regulation of Androgen receptor activity
il6_7pathway
IL6-mediated signaling events
Cross-References
SwissProt Q9R1E0
TrEMBL Q8BRS7 Q8CA93
UniProt Splice Variant
Entrez Gene 56458
UniGene Mm.29891 Mm.403212 Mm.408547
RefSeq NM_019739
OMIM
CCDS CCDS17343
HPRD
IMGT
MGI ID MGI:1890077
MGI Symbol Foxo1
EMBL AF126056 AJ252157 AK039265 AK043583 AK137629 AK154041 CH466530
GenPept AAD40636 BAC30298 BAC31588 BAE23437 BAE32333 CAB86873 EDL35224
RNA Seq Atlas 56458

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca