Version 5.4
Mus musculus Gene: Ube2m
Summary
InnateDB Gene IDBG-144148.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube2m
Gene Name ubiquitin-conjugating enzyme E2M
Synonyms 2510040H03Rik; Ubc-rs2; UBC12
Species Mus musculus
Ensembl Gene ENSMUSG00000005575
Encoded Proteins
IDBP-144150
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
IDBP-532300
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
IDBP-533366
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
IDBP-539649
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
IDBP-621824
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130725:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:13035120-13038275
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000005714 ENSMUSP00000005714
ENSMUST00000131837
ENSMUST00000125964 ENSMUSP00000122638
ENSMUST00000123541 ENSMUSP00000120234
ENSMUST00000138357
ENSMUST00000156389 ENSMUSP00000117123
ENSMUST00000126827
ENSMUST00000165394 ENSMUSP00000132604
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0018169 ribosomal S6-glutamic acid ligase activity
GO:0019788 NEDD8 ligase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0008152 metabolic process
GO:0016567 protein ubiquitination
GO:0043525 positive regulation of neuron apoptotic process
GO:0045116 protein neddylation
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130725
View Gene Order
ENSBTAG00000012744
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_189085
Disease pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_203510
TGF-beta receptor signaling activates SMADs pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_221739
Loss of Function of TGFBR1 in Cancer pathway
REACT_217678
Signaling by TGF-beta Receptor Complex pathway
REACT_220609
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_207152
Loss of Function of SMAD4 in Cancer pathway
REACT_209241
Loss of Function of TGFBR2 in Cancer pathway
REACT_211897
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_214353
Signal Transduction pathway
REACT_220430
TGF-beta receptor signaling activates SMADs pathway
REACT_211138
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_207908
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_207832
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_216195
Loss of Function of SMAD2/3 in Cancer pathway
REACT_220643
TGFBR1 LBD Mutants in Cancer pathway
REACT_207087
Disease pathway
REACT_209664
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_223905
TGFBR1 KD Mutants in Cancer pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
erb_genomic_pathway
Validated nuclear estrogen receptor beta network
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001168469 NM_001243968 NM_145578 XM_006539732
OMIM
CCDS CCDS20825 CCDS52024
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca