Mus musculus Gene: Ube2m | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-144148.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Ube2m | ||||||||||||||||||||||
Gene Name | ubiquitin-conjugating enzyme E2M | ||||||||||||||||||||||
Synonyms | 2510040H03Rik; Ubc-rs2; UBC12 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000005575 | ||||||||||||||||||||||
Encoded Proteins |
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130725:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 7:13035120-13038275 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | A1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Disease pathway
Loss of Function of SMAD4 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
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KEGG |
Ubiquitin mediated proteolysis pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
TGF-beta receptor signaling activates SMADs pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Adaptive Immune System pathway
Immune System pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Class I MHC mediated antigen processing & presentation pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signal Transduction pathway
TGF-beta receptor signaling activates SMADs pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Disease pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
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KEGG |
Ubiquitin mediated proteolysis pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_001168469 NM_001243968 NM_145578 XM_006539732 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS20825 CCDS52024 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||