Version 5.4
Mus musculus Gene: Tubb4b
Summary
InnateDB Gene IDBG-144350.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tubb4b
Gene Name tubulin, beta 4B class IVB
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000036752
Encoded Proteins
IDBP-144352
tubulin, beta 2C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188229:
Gene Information
Type Protein coding
Genomic Location Chromosome 2:25222160-25224702
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000043584 ENSMUSP00000042342
ENSMUST00000145607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0019904 protein domain specific binding
GO:0032403 protein complex binding
GO:0032794 GTPase activating protein binding
GO:0042288 MHC class I protein binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007017 microtubule-based process
GO:0051225 spindle assembly
GO:0051258 protein polymerization
Cellular Component
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0043234 protein complex
GO:0044297 cell body
GO:0045298 tubulin complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188229
View Gene Order
ENSBTAG00000025274
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
KEGG
mmu04540
Gap junction pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15510
Recruitment of NuMA to mitotic centrosomes pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_25201
Kinesins pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_16967
Post-chaperonin tubulin folding pathway pathway
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_16956
Formation of tubulin folding intermediates by CCT/TriC pathway
REACT_11039
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway
REACT_11050
Transport of connexons to the plasma membrane pathway
REACT_9509
Gap junction assembly pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_16952
Protein folding pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111045
Developmental Biology pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_9411
Gap junction trafficking pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_115566
Cell Cycle pathway
REACT_267716
Orphan transporters pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_604
Hemostasis pathway
REACT_11123
Membrane Trafficking pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_223914
G2/M Transition pathway
REACT_223239
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_223433
Recycling pathway of L1 pathway
REACT_215067
Factors involved in megakaryocyte development and platelet production pathway
REACT_216366
M Phase pathway
REACT_215526
L1CAM interactions pathway
REACT_212887
Separation of Sister Chromatids pathway
REACT_215084
Mitotic Metaphase and Anaphase pathway
REACT_211185
Mitotic Anaphase pathway
REACT_217718
Translocation of GLUT4 to the plasma membrane pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_205006
Loss of Nlp from mitotic centrosomes pathway
REACT_217933
Mitotic G2-G2/M phases pathway
REACT_222513
Kinesins pathway
REACT_203998
Gap junction trafficking pathway
REACT_214934
Cell Cycle pathway
REACT_214353
Signal Transduction pathway
REACT_203284
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_207055
Gap junction assembly pathway
REACT_219091
Chaperonin-mediated protein folding pathway
REACT_214350
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_270061
Hedgehog 'off' state pathway
REACT_203140
Axon guidance pathway
REACT_211133
MHC class II antigen presentation pathway
REACT_213782
Metabolism of proteins pathway
REACT_224535
Gap junction trafficking and regulation pathway
REACT_215331
Recruitment of NuMA to mitotic centrosomes pathway
REACT_215927
Protein folding pathway
REACT_209545
Resolution of Sister Chromatid Cohesion pathway
REACT_214469
Adaptive Immune System pathway
REACT_241835
Signaling by Hedgehog pathway
REACT_224118
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_204570
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway
REACT_215812
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_210400
Centrosome maturation pathway
REACT_203101
Mitotic Prometaphase pathway
REACT_220423
Transport of connexons to the plasma membrane pathway
REACT_220844
Developmental Biology pathway
REACT_214148
Formation of tubulin folding intermediates by CCT/TriC pathway
REACT_213260
Membrane Trafficking pathway
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04540
Gap junction pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt P68372
TrEMBL G3UZR1 Q9CVR0
UniProt Splice Variant
Entrez Gene 227613
UniGene Mm.227260
RefSeq NM_146116
OMIM
CCDS CCDS15753
HPRD
IMGT
MGI ID MGI:1915472
MGI Symbol Tubb4b
EMBL AK006924 AK146587 AK167022 AL732309 BC005547 BC022919 BC083319 CR974451
GenPept AAH05547 AAH22919 AAH83319 BAB24792 BAE27282 BAE39195 CAM14671
RNA Seq Atlas 227613

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca