Version 5.4
| Mus musculus Gene: Tceb2 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-144553.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Tceb2 | ||||||||||||||||||||||
| Gene Name | transcription elongation factor B (SIII), polypeptide 2 | ||||||||||||||||||||||
| Synonyms | 0610040H15Rik | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000055839 | ||||||||||||||||||||||
| Encoded Proteins |
transcription elongation factor B (SIII), polypeptide 2
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] TCEB2 is a part of Elongin BC complex, is a component of a multiprotein SOCS1 complex that attenuates JAK/STAT signaling by binding to JAK2 and inhibiting JAK2 kinase and by interacting with SOCS box, the Elongin BC complex can increase expression of the SOCS1 protein by inhibiting its degradation.
[Homo sapiens] TCEB2, as a part of the Elongin B and C complex, is bound by SOCS protein for proteasomal degradation.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103363:
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 17:23824740-23829109 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | A3.3 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Class I MHC mediated antigen processing & presentation pathway
Cellular responses to stress pathway
Cellular response to hypoxia pathway
Immune System pathway
Formation of RNA Pol II elongation complex pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
RNA Polymerase II Transcription Elongation pathway
RNA Polymerase II Pre-transcription Events pathway
Gene Expression pathway
Adaptive Immune System pathway
RNA Polymerase II Transcription pathway
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| KEGG |
Renal cell carcinoma pathway
Ubiquitin mediated proteolysis pathway
Pathways in cancer pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
Vif-mediated degradation of APOBEC3G pathway
Tat-mediated HIV elongation arrest and recovery pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
RNA Polymerase II Pre-transcription Events pathway
Formation of RNA Pol II elongation complex pathway
RNA Polymerase II Transcription Elongation pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
Pausing and recovery of HIV elongation pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
HIV elongation arrest and recovery pathway
Transcription of the HIV genome pathway
Late Phase of HIV Life Cycle pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
Cellular responses to stress pathway
HIV Transcription Elongation pathway
Adaptive Immune System pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
RNA Polymerase II Transcription pathway
Immune System pathway
Cellular response to hypoxia pathway
HIV Life Cycle pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
Host Interactions of HIV factors pathway
Gene Expression pathway
Disease pathway
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| KEGG |
Renal cell carcinoma pathway
Ubiquitin mediated proteolysis pathway
Pathways in cancer pathway
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| INOH | |||||||||||||||||||||||
| PID NCI |
HIF-2-alpha transcription factor network
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | |||||||||||||||||||||||
| RefSeq | NM_026305 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS57055 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||