InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS15

Summary

InnateDB Gene

IDBG-14488.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS15

Gene Name

ribosomal protein S15

Synonyms

RIG; S15

Species

Homo sapiens

Ensembl Gene

ENSG00000115268

Encoded Proteins

IDBP-812853

ribosomal protein S15

IDBP-765514

IDBP-762288

IDBP-812858

ribosomal protein S15

IDBP-764580

IDBP-762206

IDBP-812864

ribosomal protein S15

IDBP-763206

IDBP-766247

IDBP-812860

ribosomal protein S15

IDBP-812862

ribosomal protein S15

IDBP-812865

ribosomal protein S15

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:1438358-1440494

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000233609	ENSP00000473953
ENST00000592588	ENSP00000467466
ENST00000586686	ENSP00000467676
ENST00000592700
ENST00000591032	ENSP00000474970
ENST00000585665	ENSP00000466366
ENST00000589656	ENSP00000467855
ENST00000591804	ENSP00000474543
ENST00000593052	ENSP00000466010
ENST00000586096	ENSP00000465055
ENST00000592623	ENSP00000474433
ENST00000586656	ENSP00000475096
ENST00000617694	ENSP00000483399

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	76 [view]
Protein-Protein	75 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000056	ribosomal small subunit export from nucleus
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001649	osteoblast differentiation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0042274	ribosomal small subunit biogenesis
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit