InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Actr1b

Summary

InnateDB Gene

IDBG-144990.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Actr1b

Gene Name

ARP1 actin-related protein 1B, centractin beta

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037351

Encoded Proteins

IDBP-144992

ARP1 actin-related protein 1 homolog B, centractin beta (yeast)

IDBP-541693

ARP1 actin-related protein 1 homolog B, centractin beta (yeast)

IDBP-539763

ARP1 actin-related protein 1 homolog B, centractin beta (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115073:
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90%% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:36698116-36714422

Strand

Reverse strand

Band

Transcripts

ENSMUST00000043951	ENSMUSP00000047326
ENSMUST00000159675
ENSMUST00000162684
ENSMUST00000159448	ENSMUSP00000124343
ENSMUST00000160084	ENSMUSP00000125472
ENSMUST00000160043
ENSMUST00000162662

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000115073

View Gene Order

Pathways

NETPATH

REACTOME

REACT_230745

Immune System pathway

REACT_196550

MHC class II antigen presentation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_121399

MHC class II antigen presentation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.28521 Mm.431610

RefSeq

NM_146107 XM_006495910

OMIM

CCDS

CCDS14887

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas