InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ehd2

Summary

InnateDB Gene

IDBG-145700.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ehd2

Gene Name

EH-domain containing 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074364

Encoded Proteins

IDBP-145702

EH-domain containing 2

IDBP-541225

EH-domain containing 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000024422:
This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:15946977-15967567

Strand

Reverse strand

Band

Transcripts

ENSMUST00000098799	ENSMUSP00000096397
ENSMUST00000144956	ENSMUSP00000119933

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006897	endocytosis
GO:0030866	cortical actin cytoskeleton organization
GO:0032456	endocytic recycling
GO:0072659	protein localization to plasma membrane
GO:1901741	positive regulation of myoblast fusion
GO:2001137	positive regulation of endocytic recycling

Cellular Component

GO:0005886	plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000024422

View Gene Order

ENSBTAG00000021191

Not yet available

Pathways

NETPATH

REACTOME

REACT_224553

Hemostasis pathway

REACT_198649

Factors involved in megakaryocyte development and platelet production pathway

KEGG

mmu04144

Endocytosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

D3Z7U7

UniProt Splice Variant

Entrez Gene

259300

UniGene

Mm.138215 Mm.490293

RefSeq

NM_153068

OMIM

CCDS

CCDS20842

HPRD

IMGT

MGI ID

MGI:2154274

MGI Symbol

Ehd2

EMBL

AC148990

GenPept

RNA Seq Atlas

259300