InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: YWHAE

Summary

InnateDB Gene

IDBG-14629.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YWHAE

Gene Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

Synonyms

14-3-3E; HEL2; KCIP-1; MDCR; MDS

Species

Homo sapiens

Ensembl Gene

ENSG00000108953

Encoded Proteins

IDBP-14631

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

IDBP-758151

IDBP-761454

IDBP-761970

IDBP-763713

IDBP-763243

IDBP-760467

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20462248

YWHAE (14-3-3 epsilon) interacts with key components of mitogen-activated protein kinase (MAPK)signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity.

Entrez Gene

Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100%% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:1344272-1400378

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000264335	ENSP00000264335
ENST00000466227	ENSP00000464883
ENST00000496706	ENSP00000466324
ENST00000469398
ENST00000486241
ENST00000489287
ENST00000498643
ENST00000576854
ENST00000575977	ENSP00000460712
ENST00000571732	ENSP00000461762
ENST00000573026	ENSP00000458386
ENST00000572108
ENST00000573196	ENSP00000461766

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 439 experimentally validated interaction(s) in this database.
They are also associated with 142 interaction(s) predicted by orthology.

Experimentally validated
Total	439 [view]
Protein-Protein	433 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	142 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015459	potassium channel regulator activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0023026	MHC class II protein complex binding
GO:0032403	protein complex binding
GO:0042826	histone deacetylase binding
GO:0044325	ion channel binding
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity
GO:0050815	phosphoserine binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001764	neuron migration
GO:0003064	regulation of heart rate by hormone
GO:0006605	protein targeting
GO:0006915	apoptotic process
GO:0016032	viral process
GO:0021762	substantia nigra development
GO:0021766	hippocampus development
GO:0021987	cerebral cortex development
GO:0035308	negative regulation of protein dephosphorylation
GO:0035329	hippo signaling
GO:0035556	intracellular signal transduction
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0060306	regulation of membrane repolarization
GO:0061024	membrane organization
GO:0086013	membrane repolarization during cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:0097190	apoptotic signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901016	regulation of potassium ion transmembrane transporter activity
GO:1902309	negative regulation of peptidyl-serine dephosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0016020	membrane
GO:0030424	axon
GO:0030659	cytoplasmic vesicle membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome