Version 5.4
Mus musculus Gene: St14
Summary
InnateDB Gene IDBG-146547.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol St14
Gene Name suppression of tumorigenicity 14 (colon carcinoma)
Synonyms Epithin; matriptase; mCAP3; MT-SP1; Prss14; Tmprss14
Species Mus musculus
Ensembl Gene ENSMUSG00000031995
Encoded Proteins
IDBP-146549
suppression of tumorigenicity 14 (colon carcinoma)
IDBP-539923
suppression of tumorigenicity 14 (colon carcinoma)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149418:
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:31089402-31131853
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000034478 ENSMUSP00000034478
ENSMUST00000148789
ENSMUST00000133904
ENSMUST00000123557 ENSMUSP00000121971
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016477 cell migration
GO:0030216 keratinocyte differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0019897 extrinsic component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000149418
View Gene Order
ENSBTAG00000019712
Not yet available
Cross-References
SwissProt P56677
TrEMBL D6RIN3 Q543E3
UniProt Splice Variant
Entrez Gene 19143
UniGene Mm.243926
RefSeq NM_011176 XM_006510098 XM_006510100
OMIM
CCDS CCDS22948
HPRD
IMGT
MGI ID MGI:1338881
MGI Symbol St14
EMBL AC114542 AF042822 AK052738 AK166745 BC005496 CT025653
GenPept AAD02230 AAH05496 BAC35125 BAE38987
RNA Seq Atlas 19143

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca