InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ogdh

Summary

InnateDB Gene

IDBG-146734.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ogdh

Gene Name

oxoglutarate dehydrogenase (lipoamide)

Synonyms

2210403E04Rik; 2210412K19Rik; AA409584; d1401; mKIAA4192

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020456

Encoded Proteins

IDBP-146736

oxoglutarate dehydrogenase (lipoamide)

IDBP-146740

oxoglutarate dehydrogenase (lipoamide)

IDBP-146744

oxoglutarate dehydrogenase (lipoamide)

IDBP-146746

oxoglutarate dehydrogenase (lipoamide)

IDBP-534647

oxoglutarate dehydrogenase (lipoamide)

IDBP-537041

oxoglutarate dehydrogenase (lipoamide)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105953:
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:6291633-6356642

Strand

Forward strand

Band

Transcripts

ENSMUST00000003461	ENSMUSP00000003461
ENSMUST00000093350	ENSMUSP00000091041
ENSMUST00000101554	ENSMUSP00000099090
ENSMUST00000081894	ENSMUSP00000080569
ENSMUST00000125929
ENSMUST00000140765	ENSMUSP00000117323
ENSMUST00000135124	ENSMUSP00000117505

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976	thiamine pyrophosphate binding
GO:0031072	heat shock protein binding
GO:0034602	oxoglutarate dehydrogenase (NAD+) activity
GO:0046872	metal ion binding
GO:0051087	chaperone binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006096	glycolytic process
GO:0006099	tricarboxylic acid cycle
GO:0006103	2-oxoglutarate metabolic process
GO:0006104	succinyl-CoA metabolic process
GO:0006734	NADH metabolic process
GO:0008152	metabolic process
GO:0021695	cerebellar cortex development
GO:0021756	striatum development
GO:0021766	hippocampus development
GO:0021794	thalamus development
GO:0021860	pyramidal neuron development
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb
GO:0055114	oxidation-reduction process
GO:0061034	olfactory bulb mitral cell layer development