Version 5.4
Mus musculus Gene: Fhl1
Summary
InnateDB Gene IDBG-146975.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fhl1
Gene Name four and a half LIM domains 1
Synonyms FHL-1; KyoT; RAM14-1; SLIM; SLIM-1
Species Mus musculus
Ensembl Gene ENSMUSG00000023092
Encoded Proteins
IDBP-146977
four and a half LIM domains 1
IDBP-251059
four and a half LIM domains 1
IDBP-251061
four and a half LIM domains 1
IDBP-251067
four and a half LIM domains 1
IDBP-251069
four and a half LIM domains 1
IDBP-273732
four and a half LIM domains 1
IDBP-540833
four and a half LIM domains 1
IDBP-540826
four and a half LIM domains 1
IDBP-540816
four and a half LIM domains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000022267:
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:56731787-56793346
Strand Forward strand
Band A6
Transcripts
ENSMUST00000023854 ENSMUSP00000023854
ENSMUST00000114773 ENSMUSP00000110421
ENSMUST00000114772 ENSMUSP00000110420
ENSMUST00000114769 ENSMUSP00000110417
ENSMUST00000114768 ENSMUSP00000110416
ENSMUST00000116596 ENSMUSP00000112295
ENSMUST00000155882 ENSMUSP00000115700
ENSMUST00000144600 ENSMUSP00000116725
ENSMUST00000151033 ENSMUSP00000119828
ENSMUST00000153401
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044325 ion channel binding
Biological Process
GO:0003254 regulation of membrane depolarization
GO:0007275 multicellular organismal development
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0043268 positive regulation of potassium ion transport
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000022267
View Gene Order
ENSBTAG00000018513
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt P97447
TrEMBL A2AEX9 A2AEY0
UniProt Splice Variant
Entrez Gene 14199
UniGene Mm.3126 Mm.460363
RefSeq NM_001077361 NM_001077362 NM_001287800 NM_010211 XM_006527800 XM_006527801 XM_006527802 XM_006527803 XM_006527804 XM_006527805 XM_006527806 XM_006527807
OMIM
CCDS CCDS30148 CCDS40980 CCDS40981
HPRD
IMGT
MGI ID MGI:1298387
MGI Symbol Fhl1
EMBL AF114380 AL671998 BC029024 BC031120 U41739 U77039
GenPept AAC02727 AAC02805 AAD53229 AAH29024 AAH31120
RNA Seq Atlas 14199

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca