InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hnrnpa2b1

Summary

InnateDB Gene

IDBG-147385.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnpa2b1

Gene Name

heterogeneous nuclear ribonucleoprotein A2/B1

Synonyms

9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004980

Encoded Proteins

IDBP-147387

heterogeneous nuclear ribonucleoprotein A2/B1

IDBP-147389

heterogeneous nuclear ribonucleoprotein A2/B1

IDBP-251726

heterogeneous nuclear ribonucleoprotein A2/B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122566:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:51460434-51469894

Strand

Reverse strand

Band

Transcripts

ENSMUST00000090002	ENSMUSP00000087453
ENSMUST00000069949	ENSMUSP00000067491
ENSMUST00000114459	ENSMUSP00000110103

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	84 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043047	single-stranded telomeric DNA binding
GO:0044822	poly(A) RNA binding
GO:0097157	pre-mRNA intronic binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0048025	negative regulation of mRNA splicing, via spliceosome
GO:0050658	RNA transport

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0071013	catalytic step 2 spliceosome