Version 5.4
Mus musculus Gene: Sec63
Summary
InnateDB Gene IDBG-147682.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sec63
Gene Name SEC63-like (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000019802
Encoded Proteins
IDBP-147684
SEC63-like (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000025796:
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:42761496-42832514
Strand Forward strand
Band B2
Transcripts
ENSMUST00000019937 ENSMUSP00000019937
ENSMUST00000105496
ENSMUST00000155410
ENSMUST00000144228
ENSMUST00000124613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001889 liver development
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006620 posttranslational protein targeting to membrane
GO:0006807 nitrogen compound metabolic process
GO:0010259 multicellular organismal aging
GO:0031204 posttranslational protein targeting to membrane, translocation
GO:0072001 renal system development
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000025796
View Gene Order
ENSBTAG00000016562
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03060
Protein export pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03060
Protein export pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q8VHE0
TrEMBL Q8K2U5
UniProt Splice Variant
Entrez Gene 140740
UniGene Mm.214344 Mm.401237
RefSeq NM_153055 XM_006512532
OMIM
CCDS CCDS23815
HPRD
IMGT
MGI ID MGI:2155302
MGI Symbol Sec63
EMBL AC124998 AY024346 BC019366 BC029774 BC031846
GenPept AAH19366 AAH29774 AAH31846 AAK00580
RNA Seq Atlas 140740

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca