Version 5.4
Mus musculus Gene: Ucn
Summary
InnateDB Gene IDBG-147728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ucn
Gene Name urocortin
Synonyms Mpv17; Ucn1
Species Mus musculus
Ensembl Gene ENSMUSG00000038676
Encoded Proteins
IDBP-147730
urocortin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163794:
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:31138063-31138829
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000043475 ENSMUSP00000035321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0046811 histone deacetylase inhibitor activity
GO:0051430 corticotropin-releasing hormone receptor 1 binding
GO:0051431 corticotropin-releasing hormone receptor 2 binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0007218 neuropeptide signaling pathway
GO:0007565 female pregnancy
GO:0007611 learning or memory
GO:0007631 feeding behavior
GO:0008306 associative learning
GO:0009060 aerobic respiration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0030157 pancreatic juice secretion
GO:0030307 positive regulation of cell growth
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031064 negative regulation of histone deacetylation
GO:0031175 neuron projection development
GO:0032099 negative regulation of appetite
GO:0032355 response to estradiol
GO:0032755 positive regulation of interleukin-6 production
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034199 activation of protein kinase A activity
GO:0035176 social behavior
GO:0035483 gastric emptying
GO:0042756 drinking behavior
GO:0043066 negative regulation of apoptotic process
GO:0043117 positive regulation of vascular permeability
GO:0045727 positive regulation of translation
GO:0045740 positive regulation of DNA replication
GO:0045776 negative regulation of blood pressure
GO:0045792 negative regulation of cell size
GO:0045909 positive regulation of vasodilation
GO:0046888 negative regulation of hormone secretion
GO:0048265 response to pain
GO:0051384 response to glucocorticoid
GO:0051461 positive regulation of corticotropin secretion
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060452 positive regulation of cardiac muscle contraction
GO:0060455 negative regulation of gastric acid secretion
GO:0060547 negative regulation of necrotic cell death
GO:0060548 negative regulation of cell death
GO:0090280 positive regulation of calcium ion import
GO:1901215 negative regulation of neuron death
GO:2000252 negative regulation of feeding behavior
GO:2000987 positive regulation of behavioral fear response
Cellular Component
GO:0005576 extracellular region
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043196 varicosity
GO:0043204 perikaryon
GO:0043679 axon terminus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163794
View Gene Order
ENSBTAG00000018268
Not yet available
Cross-References
SwissProt P81615
TrEMBL Q14A76
UniProt Splice Variant
Entrez Gene 22226
UniGene Mm.377116
RefSeq NM_021290
OMIM
CCDS CCDS19174
HPRD
IMGT
MGI ID MGI:1276123
MGI Symbol Ucn
EMBL AF038632 BC116948 BC116950 BC144891 CH466524
GenPept AAC24202 AAI16949 AAI16951 AAI44892 EDL37339
RNA Seq Atlas 22226

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca