Version 5.4
Mus musculus Gene: Lhx3
Summary
InnateDB Gene IDBG-147872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lhx3
Gene Name LIM homeobox protein 3
Synonyms Lim3; mLim-3; mLIM3; P-LIM
Species Mus musculus
Ensembl Gene ENSMUSG00000026934
Encoded Proteins
IDBP-147874
LIM homeobox protein 3
IDBP-147876
LIM homeobox protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107187:
This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:26200212-26208289
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000054099 ENSMUSP00000056822
ENSMUST00000028302 ENSMUSP00000028302
ENSMUST00000127035
ENSMUST00000149637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001890 placenta development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0008045 motor neuron axon guidance
GO:0009953 dorsal/ventral pattern formation
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021521 ventral spinal cord interneuron specification
GO:0021526 medial motor column neuron differentiation
GO:0021527 spinal cord association neuron differentiation
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0043066 negative regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048839 inner ear development
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107187
View Gene Order
ENSBTAG00000011124
Not yet available
Cross-References
SwissProt P50481
TrEMBL A2ALD9 Q8C8F2
UniProt Splice Variant
Entrez Gene 16871
UniGene Mm.386765
RefSeq NM_010711 XM_006497740 XM_006497741 NM_001039653
OMIM
CCDS CCDS71004 CCDS38081
HPRD
IMGT
MGI ID MGI:102673
MGI Symbol Lhx3
EMBL AK047273 BC150689 L33776 L38248 L38249 L38857
GenPept AAA62369 AAA73902 AAA98998 AAB64178 AAI50690 BAC33011
RNA Seq Atlas 16871

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca