InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Igf2bp2

Summary

InnateDB Gene

IDBG-147890.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Igf2bp2

Gene Name

insulin-like growth factor 2 mRNA binding protein 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033581

Encoded Proteins

IDBP-147892

insulin-like growth factor 2 mRNA binding protein 2

IDBP-249773

insulin-like growth factor 2 mRNA binding protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073792:
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5\' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:22059009-22163299

Strand

Reverse strand

Band

Transcripts

ENSMUST00000100052	ENSMUSP00000097629
ENSMUST00000115379	ENSMUSP00000111037
ENSMUST00000129913
ENSMUST00000134188
ENSMUST00000124318
ENSMUST00000146885
ENSMUST00000151087
ENSMUST00000125926
ENSMUST00000127696

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0048027	mRNA 5'-UTR binding

Biological Process

GO:0006417	regulation of translation
GO:0051028	mRNA transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000073792

View Gene Order

ENSBTAG00000007666

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22166

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.489442 Mm.491007

RefSeq

NM_183029

OMIM

CCDS

CCDS49797

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas