InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prkch

Summary

InnateDB Gene

IDBG-148471.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkch

Gene Name

protein kinase C, eta

Synonyms

Pkch

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021108

Encoded Proteins

IDBP-148473

protein kinase C, eta

IDBP-401491

protein kinase C, eta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000027075:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:73584797-73778185

Strand

Forward strand

Band

Transcripts

ENSMUST00000021527	ENSMUSP00000021527
ENSMUST00000119092	ENSMUSP00000112499

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004699	calcium-independent protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017160	Ral GTPase binding
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0034351	negative regulation of glial cell apoptotic process
GO:0035556	intracellular signal transduction
GO:0045618	positive regulation of keratinocyte differentiation
GO:0050861	positive regulation of B cell receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060252	positive regulation of glial cell proliferation
GO:0070528	protein kinase C signaling
GO:2000810	regulation of tight junction assembly