Version 5.4
Homo sapiens Gene: INPP5K
Summary
InnateDB Gene IDBG-14904.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INPP5K
Gene Name inositol polyphosphate-5-phosphatase K
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132376
Encoded Proteins
IDBP-14906
inositol polyphosphate-5-phosphatase K
IDBP-14908
inositol polyphosphate-5-phosphatase K
IDBP-292480
inositol polyphosphate-5-phosphatase K
IDBP-360914
inositol polyphosphate-5-phosphatase K
IDBP-360918
inositol polyphosphate-5-phosphatase K
IDBP-360920
inositol polyphosphate-5-phosphatase K
IDBP-759887
IDBP-759669
IDBP-759423
IDBP-761302
IDBP-758353
IDBP-763682
IDBP-760714
IDBP-762547
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:1494571-1516888
Strand Reverse strand
Band p13.3
Transcripts
ENST00000320345 ENSP00000318476
ENST00000350761 ENSP00000254712
ENST00000406424 ENSP00000385177
ENST00000421807 ENSP00000413937
ENST00000449479 ENSP00000413259
ENST00000445774 ENSP00000389334
ENST00000487039
ENST00000461552
ENST00000495339
ENST00000481867
ENST00000477115
ENST00000460733
ENST00000477910 ENSP00000467376
ENST00000498390 ENSP00000466929
ENST00000574955 ENSP00000459029
ENST00000576646 ENSP00000466632
ENST00000571274 ENSP00000458413
ENST00000575172 ENSP00000459758
ENST00000574561 ENSP00000461105
ENST00000573790 ENSP00000461846
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005000 vasopressin receptor activity
GO:0005515 protein binding
GO:0016312 inositol bisphosphate phosphatase activity
GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity
GO:0042577 lipid phosphatase activity
GO:0046030 inositol trisphosphate phosphatase activity
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
Biological Process
GO:0001701 in utero embryonic development
GO:0001933 negative regulation of protein phosphorylation
GO:0005979 regulation of glycogen biosynthetic process
GO:0006469 negative regulation of protein kinase activity
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010829 negative regulation of glucose transport
GO:0016311 dephosphorylation
GO:0030036 actin cytoskeleton organization
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032870 cellular response to hormone stimulus
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035305 negative regulation of dephosphorylation
GO:0035810 positive regulation of urine volume
GO:0042593 glucose homeostasis
GO:0043407 negative regulation of MAP kinase activity
GO:0043922 negative regulation by host of viral transcription
GO:0044281 small molecule metabolic process
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0051497 negative regulation of stress fiber assembly
GO:0051898 negative regulation of protein kinase B signaling
GO:0051926 negative regulation of calcium ion transport
GO:0071320 cellular response to cAMP
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0072661 protein targeting to plasma membrane
GO:0090315 negative regulation of protein targeting to membrane
GO:0097178 ruffle assembly
GO:2000466 negative regulation of glycogen (starch) synthase activity
GO:2001153 positive regulation of renal water transport
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032587 ruffle membrane
GO:0043005 neuron projection
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006127
View Gene Order
ENSBTAG00000011479
Not yet available
Pathways
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04910
Insulin signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL I3L4A5
UniProt Splice Variant
Entrez Gene 51763
UniGene Hs.632238
RefSeq NM_001135642 NM_016532 NM_130766 XM_005256683 XM_006721545
HUGO HGNC:33882
OMIM 607875
CCDS CCDS11004 CCDS11005
HPRD 08489
IMGT
EMBL AC100748
GenPept
RNA Seq Atlas 51763

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca