InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aqp1

Summary

InnateDB Gene

IDBG-150000.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aqp1

Gene Name

aquaporin 1

Synonyms

CHIP28

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004655

Encoded Proteins

IDBP-150002

aquaporin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000240583:
Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:55336432-55348555

Strand

Forward strand

Band

Transcripts

ENSMUST00000004774

ENSMUSP00000004774

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005223	intracellular cGMP activated cation channel activity
GO:0005267	potassium channel activity
GO:0005372	water transmembrane transporter activity
GO:0005515	protein binding
GO:0008519	ammonium transmembrane transporter activity
GO:0015079	potassium ion transmembrane transporter activity
GO:0015168	glycerol transmembrane transporter activity
GO:0015250	water channel activity
GO:0022857	transmembrane transporter activity
GO:0030184	nitric oxide transmembrane transporter activity
GO:0035379	carbon dioxide transmembrane transporter activity
GO:0046875	ephrin receptor binding

Biological Process

GO:0003094	glomerular filtration
GO:0003097	renal water transport
GO:0006182	cGMP biosynthetic process
GO:0006810	transport
GO:0006813	potassium ion transport
GO:0006833	water transport
GO:0006884	cell volume homeostasis
GO:0006972	hyperosmotic response
GO:0009725	response to hormone
GO:0010592	positive regulation of lamellipodium assembly
GO:0010634	positive regulation of epithelial cell migration
GO:0015670	carbon dioxide transport
GO:0015696	ammonium transport
GO:0015793	glycerol transport
GO:0019233	sensory perception of pain
GO:0019725	cellular homeostasis
GO:0021670	lateral ventricle development
GO:0030104	water homeostasis
GO:0030157	pancreatic juice secretion
GO:0030185	nitric oxide transport
GO:0030335	positive regulation of cell migration
GO:0030950	establishment or maintenance of actin cytoskeleton polarity
GO:0032940	secretion by cell
GO:0033326	cerebrospinal fluid secretion
GO:0033363	secretory granule organization
GO:0033554	cellular response to stress
GO:0034644	cellular response to UV
GO:0035377	transepithelial water transport
GO:0035378	carbon dioxide transmembrane transport
GO:0042060	wound healing
GO:0042476	odontogenesis
GO:0042493	response to drug
GO:0042538	hyperosmotic salinity response
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043627	response to estrogen
GO:0044241	lipid digestion
GO:0045766	positive regulation of angiogenesis
GO:0046878	positive regulation of saliva secretion
GO:0048146	positive regulation of fibroblast proliferation
GO:0048593	camera-type eye morphogenesis
GO:0050891	multicellular organismal water homeostasis
GO:0051458	corticotropin secretion
GO:0070295	renal water absorption
GO:0070301	cellular response to hydrogen peroxide
GO:0071241	cellular response to inorganic substance
GO:0071260	cellular response to mechanical stimulus
GO:0071280	cellular response to copper ion
GO:0071288	cellular response to mercury ion
GO:0071300	cellular response to retinoic acid
GO:0071320	cellular response to cAMP
GO:0071456	cellular response to hypoxia
GO:0071472	cellular response to salt stress
GO:0071474	cellular hyperosmotic response
GO:0071549	cellular response to dexamethasone stimulus
GO:0071732	cellular response to nitric oxide
GO:0071805	potassium ion transmembrane transport
GO:0072220	metanephric descending thin limb development
GO:0072230	metanephric proximal straight tubule development
GO:0072232	metanephric proximal convoluted tubule segment 2 development
GO:0072239	metanephric glomerulus vasculature development
GO:0072488	ammonium transmembrane transport
GO:0085018	maintenance of symbiont-containing vacuole by host

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0020003	symbiont-containing vacuole
GO:0020005	symbiont-containing vacuole membrane
GO:0030424	axon
GO:0031526	brush border membrane
GO:0031965	nuclear membrane
GO:0032809	neuronal cell body membrane
GO:0042383	sarcolemma
GO:0043005	neuron projection
GO:0043679	axon terminus
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome