InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fosl2

Summary

InnateDB Gene

IDBG-150675.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fosl2

Gene Name

fos-like antigen 2

Synonyms

Fra-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029135

Encoded Proteins

IDBP-150677

fos-like antigen 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075426:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2008]
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:32136472-32157831

Strand

Forward strand

Band

Transcripts

ENSMUST00000031017

ENSMUSP00000031017

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007565	female pregnancy
GO:0009612	response to mechanical stimulus
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0042493	response to drug
GO:0043278	response to morphine
GO:0048146	positive regulation of fibroblast proliferation
GO:0051412	response to corticosterone
GO:0051591	response to cAMP

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000075426

View Gene Order

ENSBTAG00000023929

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04380

Osteoclast differentiation pathway

INOH

INOH website

CD4 T cell receptor signaling pathway

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04380

Osteoclast differentiation pathway

INOH

INOH website

CD4 T cell receptor signaling pathway

PID NCI

fra_pathway

Validated transcriptional targets of AP1 family members Fra1 and Fra2

ap1_pathway

AP-1 transcription factor network

deltanp63pathway

Validated transcriptional targets of deltaNp63 isoforms

Cross-References

SwissProt

P47930

TrEMBL

UniProt Splice Variant

Entrez Gene

14284

UniGene

Mm.24684 Mm.397223 Mm.402927

RefSeq

NM_008037

OMIM

CCDS

CCDS19190

HPRD

IMGT

MGI ID

MGI:102858

MGI Symbol

Fosl2

EMBL

AK089371 AK145822 BC065131 X83970 X83971

GenPept

AAH65131 BAC40860 BAE26674 CAA58804 CAA58805

RNA Seq Atlas

14284