Version 5.4
Mus musculus Gene: Mark4
Summary
InnateDB Gene IDBG-150756.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mark4
Gene Name MAP/microtubule affinity-regulating kinase 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030397
Encoded Proteins
IDBP-150758
MAP/microtubule affinity-regulating kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000007047:
This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:19426075-19458494
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000085715 ENSMUSP00000082862
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0043015 gamma-tubulin binding
GO:0050321 tau-protein kinase activity
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001578 microtubule bundle formation
GO:0006468 protein phosphorylation
GO:0007399 nervous system development
Cellular Component
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0015630 microtubule cytoskeleton
GO:0043005 neuron projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000007047
View Gene Order
ENSBTAG00000002682
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
Cross-References
SwissProt Q8CIP4
TrEMBL Q8BZE0
UniProt Splice Variant
Entrez Gene 232944
UniGene Mm.260504
RefSeq NM_172279
OMIM
CCDS CCDS20903
HPRD
IMGT
MGI ID MGI:1920955
MGI Symbol Mark4
EMBL AK035668 AK122565 AY151083
GenPept AAN60072 BAC29146 BAC65847
RNA Seq Atlas 232944

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca