InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SCARF1

Summary

InnateDB Gene

IDBG-15121.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCARF1

Gene Name

scavenger receptor class F, member 1

Synonyms

SREC; SREC-I; SREC1

Species

Homo sapiens

Ensembl Gene

ENSG00000074660

Encoded Proteins

IDBP-15125

scavenger receptor class F, member 1

IDBP-15127

scavenger receptor class F, member 1

IDBP-360966

scavenger receptor class F, member 1

IDBP-759994

IDBP-764053

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19237602

SCARF1 mediates host defence against Cryptococcus neoformans and Candida albicans through cytokine production and is required for macrophage binding to C. neoformans to control the infection in mice.

Entrez Gene

Summary

The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells and mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Transcription factors ZNF444/EZF-2 and SP1 are found to be responsible for the regulation of this gene. Five alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:1633858-1645747

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000263071	ENSP00000263071
ENST00000348987	ENSP00000323964
ENST00000434376	ENSP00000411167
ENST00000576012
ENST00000570902
ENST00000574545
ENST00000573867
ENST00000571272	ENSP00000458174
ENST00000573852	ENSP00000461468

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0006707	cholesterol catabolic process
GO:0006898	receptor-mediated endocytosis
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0010976	positive regulation of neuron projection development
GO:0016322	neuron remodeling
GO:0016358	dendrite development
GO:0045087	innate immune response (InnateDB)
GO:0048680	positive regulation of axon regeneration

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030666	endocytic vesicle membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038188

View Gene Order

ENSBTAG00000011483

Not yet available

Pathways

NETPATH

REACTOME

REACT_163813

Scavenging by Class F Receptors pathway

REACT_160300

Binding and Uptake of Ligands by Scavenger Receptors pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.647430

RefSeq

NM_003693 NM_145350

HUGO

OMIM

CCDS

CCDS11007 CCDS45564

HPRD

06386

IMGT

EMBL

GenPept

RNA Seq Atlas