InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nsdhl

Summary

InnateDB Gene

IDBG-151446.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nsdhl

Gene Name

NAD(P) dependent steroid dehydrogenase-like

Synonyms

AI747449; Bpa; H105E3; Str; XAP104

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031349

Encoded Proteins

IDBP-151448

NAD(P) dependent steroid dehydrogenase-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147383:
The protein encoded by this gene is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis. Mutations in this gene are associated with CHILD syndrome, which is a X-linked dominant disorder of lipid metabolism with disturbed cholesterol biosynthesis, and typically lethal in males. Alternatively spliced transcript variants with differing 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:72918557-72958514

Strand

Forward strand

Band

A7.3

Transcripts

ENSMUST00000033715	ENSMUSP00000033715
ENSMUST00000155663

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0008831	dTDP-4-dehydrorhamnose reductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0047012	sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
GO:0050662	coenzyme binding

Biological Process

GO:0001942	hair follicle development
GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0007224	smoothened signaling pathway
GO:0008203	cholesterol metabolic process
GO:0009058	biosynthetic process
GO:0044237	cellular metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0055114	oxidation-reduction process
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle