Version 5.4
Mus musculus Gene: Asf1a
Summary
InnateDB Gene IDBG-151528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asf1a
Gene Name ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
Synonyms 2310079C17Rik; C79052
Species Mus musculus
Ensembl Gene ENSMUSG00000019857
Encoded Proteins
IDBP-151530
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111875:
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:53596961-53609213
Strand Forward strand
Band B3
Transcripts
ENSMUST00000020004 ENSMUSP00000020004
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0042393 histone binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006281 DNA repair
GO:0006333 chromatin assembly or disassembly
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016568 chromatin modification
GO:0042692 muscle cell differentiation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111875
View Gene Order
ENSBTAG00000002058
Not yet available
Pathways
NETPATH
REACTOME
REACT_188957
Cellular responses to stress pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_188820
Cellular Senescence pathway
REACT_209428
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169121
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
REACT_206069
Cellular responses to stress pathway
REACT_215025
Cellular Senescence pathway
REACT_211071
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
REACT_214732
DNA Damage/Telomere Stress Induced Senescence pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9CQE6
TrEMBL
UniProt Splice Variant
Entrez Gene 66403
UniGene Mm.272989
RefSeq NM_025541
OMIM
CCDS CCDS23847
HPRD
IMGT
MGI ID MGI:1913653
MGI Symbol Asf1a
EMBL AK007804 AK010210 AK012376 AK088618 BC027628
GenPept AAH27628 BAB25269 BAB26770 BAB28198 BAC40457
RNA Seq Atlas 66403

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca