Version 5.4
Mus musculus Gene: Mbl1
Summary
InnateDB Gene IDBG-151802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mbl1
Gene Name mannose-binding lectin (protein A) 1
Synonyms MBL-A; MBP-A; S-MBP
Species Mus musculus
Ensembl Gene ENSMUSG00000037780
Encoded Proteins
IDBP-151804
mannose-binding lectin (protein A) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20375621
Mbl1 interacts with Fcna and fibrinogen/fibrin to augment the lectin complement pathway, which collaborates with the coagulation system in the first-line host defence against pathogens under conditions such as injury and inflammation.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:41151456-41158959
Strand Forward strand
Band B
Transcripts
ENSMUST00000047095 ENSMUSP00000048765
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005537 mannose binding
GO:0030246 carbohydrate binding
GO:0030247 polysaccharide binding
GO:0042803 protein homodimerization activity
GO:0048306 calcium-dependent protein binding
GO:0070273 phosphatidylinositol-4-phosphate binding
Biological Process
GO:0001867 complement activation, lectin pathway
GO:0006958 complement activation, classical pathway
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0050766 positive regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0051289 protein homotetramerization
GO:0051873 killing by host of symbiont cells
GO:0070207 protein homotrimerization
Cellular Component
GO:0005581 collagen trimer
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04610
Complement and coagulation cascades pathway
mmu05150
Staphylococcus aureus infection pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt P39039
TrEMBL
UniProt Splice Variant
Entrez Gene 17194
UniGene
RefSeq NM_010775 XM_006518669
OMIM
CCDS CCDS26961
HPRD
IMGT
MGI ID MGI:96923
MGI Symbol Mbl1
EMBL BC012245 BC021762 D11441 S42292 U09007 U09008 U09009 U09010
GenPept AAA82009 AAB19342 AAH12245 AAH21762 BAA02006
RNA Seq Atlas 17194

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca