InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp2b3

Summary

InnateDB Gene

IDBG-152940.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp2b3

Gene Name

ATPase, Ca++ transporting, plasma membrane 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031376

Encoded Proteins

IDBP-152942

ATPase, Ca++ transporting, plasma membrane 3

IDBP-152944

ATPase, Ca++ transporting, plasma membrane 3

IDBP-251662

ATPase, Ca++ transporting, plasma membrane 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067842:
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:73503086-73571005

Strand

Forward strand

Band

A7.3

Transcripts

ENSMUST00000088429	ENSMUSP00000085775
ENSMUST00000033744	ENSMUSP00000033744
ENSMUST00000114479	ENSMUSP00000110123

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006812	cation transport
GO:0008152	metabolic process
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000067842

View Gene Order

ENSBTAG00000000520

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04020

Calcium signaling pathway pathway

mmu04970

Salivary secretion pathway

mmu04972

Pancreatic secretion pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_23765

Reduction of cytosolic Ca++ levels pathway

REACT_23876

Platelet homeostasis pathway

REACT_25149

Ion transport by P-type ATPases pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_23905

Platelet calcium homeostasis pathway

REACT_25300

Ion channel transport pathway

REACT_604

Hemostasis pathway

KEGG

hsa04020

Calcium signaling pathway pathway

hsa04972

Pancreatic secretion pathway

hsa04970

Salivary secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q8C048

UniProt Splice Variant

Entrez Gene

320707

UniGene

RefSeq

XM_006528086 NM_177236 XM_006528084

OMIM

CCDS

CCDS30205

HPRD

IMGT

MGI ID

MGI:1347353

MGI Symbol

Atp2b3

EMBL

AK032322 AL732461 AL805924

GenPept

BAC27813

RNA Seq Atlas

320707