Version 5.4
Mus musculus Gene: Pole3
Summary
InnateDB Gene IDBG-153516.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pole3
Gene Name polymerase (DNA directed), epsilon 3 (p17 subunit)
Synonyms 1810034K18Rik; YBL1
Species Mus musculus
Ensembl Gene ENSMUSG00000028394
Encoded Proteins
IDBP-153518
polymerase (DNA directed), epsilon 3 (p17 subunit)
IDBP-533357
polymerase (DNA directed), epsilon 3 (p17 subunit)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148229:
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:62522649-62525068
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000030091 ENSMUSP00000030091
ENSMUST00000128100 ENSMUSP00000114486
ENSMUST00000129930
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006261 DNA-dependent DNA replication
Cellular Component
GO:0005622 intracellular
GO:0008622 epsilon DNA polymerase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148229
View Gene Order
ENSBTAG00000000252
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu03030
DNA replication pathway
mmu00230
Purine metabolism pathway
mmu03420
Nucleotide excision repair pathway
mmu03410
Base excision repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa03030
DNA replication pathway
hsa00230
Purine metabolism pathway
hsa03420
Nucleotide excision repair pathway
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RDT4
UniProt Splice Variant
Entrez Gene 59001
UniGene Mm.27444 Mm.400792
RefSeq NM_021498
OMIM
CCDS CCDS18244
HPRD
IMGT
MGI ID MGI:1933378
MGI Symbol Pole3
EMBL AL732594
GenPept
RNA Seq Atlas 59001

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca