InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fech

Summary

InnateDB Gene

IDBG-153857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fech

Gene Name

ferrochelatase

Synonyms

AI894116; fch; Fcl

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024588

Encoded Proteins

IDBP-153859

ferrochelatase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066926:
The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:64456550-64489066

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025484

ENSMUSP00000025484

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004325	ferrochelatase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0020037	heme binding
GO:0030350	iron-responsive element binding
GO:0046906	tetrapyrrole binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006783	heme biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0009416	response to light stimulus
GO:0009589	detection of UV
GO:0010038	response to metal ion
GO:0010288	response to lead ion
GO:0010468	regulation of gene expression
GO:0010999	regulation of eIF2 alpha phosphorylation by heme
GO:0017085	response to insecticide
GO:0030218	erythrocyte differentiation
GO:0034379	very-low-density lipoprotein particle assembly
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0046501	protoporphyrinogen IX metabolic process
GO:0046685	response to arsenic-containing substance
GO:0046984	regulation of hemoglobin biosynthetic process
GO:0051597	response to methylmercury
GO:0055072	iron ion homeostasis
GO:0070541	response to platinum ion
GO:0071549	cellular response to dexamethasone stimulus