Version 5.4
Mus musculus Gene: Sc5d
Summary
InnateDB Gene IDBG-154324.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sc5d
Gene Name sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032018
Encoded Proteins
IDBP-154326
sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)
IDBP-625727
sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109929:
This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene have been associated with lathosterolosis. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:42254177-42264300
Strand Reverse strand
Band A5.1
Transcripts
ENSMUST00000052725 ENSMUSP00000057354
ENSMUST00000169609 ENSMUSP00000130438
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000248 C-5 sterol desaturase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0050046 lathosterol oxidase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0033490 cholesterol biosynthetic process via lathosterol
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109929
View Gene Order
ENSBTAG00000019246
Not yet available
Pathways
NETPATH
REACTOME
REACT_198969
Activation of gene expression by SREBF (SREBP) pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_208531
Cholesterol biosynthesis pathway
KEGG
mmu00100
Steroid biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_9405
Cholesterol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00100
Steroid biosynthesis pathway
INOH
INOH website
Steroids metabolism pathway
PID NCI
Cross-References
SwissProt O88822
TrEMBL
UniProt Splice Variant
Entrez Gene 235293
UniGene Mm.32700
RefSeq NM_172769 XM_006510253
OMIM
CCDS CCDS23086
HPRD
IMGT
MGI ID MGI:1353611
MGI Symbol Sc5d
EMBL AB016248 AC160051 AK043825 AK077670
GenPept BAA33730 BAC31666 BAC36944
RNA Seq Atlas 235293

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca