Version 5.4
Mus musculus Gene: Irf2
Summary
InnateDB Gene IDBG-154369.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irf2
Gene Name interferon regulatory factor 2
Synonyms 9830146E22Rik; AI646973; Irf-2
Species Mus musculus
Ensembl Gene ENSMUSG00000031627
Encoded Proteins
IDBP-154371
interferon regulatory factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18514056
[Homo sapiens] IRF2 is a transcriptional repressor that functions by competing with the transcriptional activator IRF1 and has also been shown to functions as a transcriptional activator for several genes. IRF2 transcriptional activity is regulated by sumoylation whereby covalent modification of IRF2 by SUMO1 results in enhanced transcriptional repression activity on IRF1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168310:
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:46739745-46847458
Strand Forward strand
Band B1.1
Transcripts
ENSMUST00000034041 ENSMUSP00000034041
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 5 [view]
Protein-DNA 17 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005925 focal adhesion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168310
View Gene Order
ENSBTAG00000010002
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_224553
Hemostasis pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_198521
TRAF6 mediated IRF7 activation pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24938
TRAF6 mediated IRF7 activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_25162
Interferon alpha/beta signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1149 Mm.402627
RefSeq NM_008391 XM_006509284 XM_006509285 XM_006509286 XM_006509287 XM_006509288 XM_006509289
OMIM
CCDS CCDS22295
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca