Mus musculus Gene: Lrat | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-154487.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Lrat | ||||||||||||
Gene Name | lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) | ||||||||||||
Synonyms | 1300010A18Rik; AI449251 | ||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Gene | ENSMUSG00000028003 | ||||||||||||
Encoded Proteins |
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121207:
The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. [provided by RefSeq, Jul 2008] The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 3:82892579-82903973 | ||||||||||||
Strand | Reverse strand | ||||||||||||
Band | E3 | ||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Disease pathway
Retinoid metabolism and transport pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Visual phototransduction pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
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KEGG |
Retinol metabolism pathway
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INOH | |||||||||||||
PID NCI | |||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
The canonical retinoid cycle in rods (twilight vision) pathway
Retinoid metabolism and transport pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Visual phototransduction pathway
Disease pathway
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KEGG |
Retinol metabolism pathway
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INOH | |||||||||||||
PID NCI |
Visual signal transduction: Cones
Visual signal transduction: Rods
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Cross-References | |||||||||||||
SwissProt | Q9JI60 | ||||||||||||
TrEMBL | B2RUR5 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 79235 | ||||||||||||
UniGene | Mm.33921 | ||||||||||||
RefSeq | NM_023624 | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS17430 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
MGI ID | MGI:1891259 | ||||||||||||
MGI Symbol | Lrat | ||||||||||||
EMBL | AF255061 AK004953 BC141375 BC141378 CH466547 | ||||||||||||
GenPept | AAF97787 AAI41376 AAI41379 BAB23696 EDL15427 | ||||||||||||
RNA Seq Atlas | 79235 | ||||||||||||