Version 5.4
Mus musculus Gene: Hk3
Summary
InnateDB Gene IDBG-154553.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hk3
Gene Name hexokinase 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025877
Encoded Proteins
IDBP-154555
hexokinase 3
IDBP-535936
hexokinase 3
IDBP-534404
hexokinase 3
IDBP-534643
hexokinase 3
IDBP-535790
hexokinase 3
IDBP-539162
hexokinase 3
IDBP-532815
hexokinase 3
IDBP-531798
hexokinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160883:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:55005985-55021385
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000052949 ENSMUSP00000051215
ENSMUST00000153665 ENSMUSP00000115227
ENSMUST00000132309 ENSMUSP00000117254
ENSMUST00000126234 ENSMUSP00000123233
ENSMUST00000123097 ENSMUSP00000116717
ENSMUST00000148221 ENSMUSP00000119357
ENSMUST00000149644 ENSMUSP00000121088
ENSMUST00000135983 ENSMUSP00000123489
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008865 fructokinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019158 mannokinase activity
GO:0019899 enzyme binding
GO:0042562 hormone binding
Biological Process
GO:0001678 cellular glucose homeostasis
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0019318 hexose metabolic process
GO:0046835 carbohydrate phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160883
View Gene Order
ENSBTAG00000014898
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_188937
Metabolism pathway
REACT_253543
Glucose transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_240125
Hexose transport pathway
REACT_203949
Glycogen storage diseases pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu00520
Amino sugar and nucleotide sugar metabolism pathway
mmu04930
Type II diabetes mellitus pathway
mmu00051
Fructose and mannose metabolism pathway
mmu04910
Insulin signaling pathway pathway
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu00500
Starch and sucrose metabolism pathway
mmu00052
Galactose metabolism pathway
mmu04973
Carbohydrate digestion and absorption pathway
mmu00524
Butirosin and neomycin biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_212
Glucose transport pathway
REACT_9441
Hexose transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00052
Galactose metabolism pathway
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa04910
Insulin signaling pathway pathway
hsa00500
Starch and sucrose metabolism pathway
hsa00051
Fructose and mannose metabolism pathway
hsa04930
Type II diabetes mellitus pathway
hsa04973
Carbohydrate digestion and absorption pathway
hsa00524
Butirosin and neomycin biosynthesis pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Aminosugars metabolism pathway
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.267479
RefSeq NM_001033245 NM_001206390 NM_001206391 NM_001206392
OMIM
CCDS CCDS26538 CCDS56883 CCDS56884
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca