Mus musculus Gene: Grik4
Summary
InnateDB Gene IDBG-154653.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grik4
Gene Name glutamate receptor, ionotropic, kainate 4
Synonyms 6330551K01Rik; GluK4; GluRgamma1; KA-1; KA1
Species Mus musculus
Ensembl Gene ENSMUSG00000032017
Encoded Proteins
glutamate receptor, ionotropic, kainate 4
glutamate receptor, ionotropic, kainate 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149403:
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. [provided by RefSeq, Jul 2008]
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:42518135-42944493
Strand Reverse strand
Band A5.1
Transcripts
ENSMUST00000034515 ENSMUSP00000034515
ENSMUST00000114865 ENSMUSP00000110515
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005515 protein binding
GO:0015277 kainate selective glutamate receptor activity
Biological Process
GO:0006810 transport
GO:0031960 response to corticosteroid
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0032983 kainate selective glutamate receptor complex
GO:0042734 presynaptic membrane
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Ionotropic activity of Kainate Receptors pathway
Activation of Kainate Receptors upon glutamate binding pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Activation of Ca-permeable Kainate Receptor pathway
Neuronal System pathway
Transmission across Chemical Synapses pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Neuronal System pathway
Ionotropic activity of Kainate Receptors pathway
Activation of Kainate Receptors upon glutamate binding pathway
Transmission across Chemical Synapses pathway
Activation of Ca-permeable Kainate Receptor pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt Q8BMF5
TrEMBL
UniProt Splice Variant
Entrez Gene 110637
UniGene Mm.367909 Mm.370291
RefSeq NM_175481 XM_006509943 XM_006509941
OMIM
CCDS CCDS23089
HPRD
IMGT
MGI ID MGI:95817
MGI Symbol Grik4
EMBL AC122449 AC136903 AC140387 AC160123 AK032029
GenPept BAC27660
RNA Seq Atlas 110637