InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: 1700021K19Rik

Summary

InnateDB Gene

IDBG-154810.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

1700021K19Rik

Gene Name

RIKEN cDNA 1700021K19 gene

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035629

Encoded Proteins

IDBP-154812

RIKEN cDNA 1700021K19 gene

IDBP-154814

RIKEN cDNA 1700021K19 gene

IDBP-250351

RIKEN cDNA 1700021K19 gene

IDBP-401270

RIKEN cDNA 1700021K19 gene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22423967

Rubicon is a physiological feedback inhibitor of pattern recognition receptor signalling, preventing unbalanced proinflammatory responses. (Demonstrated in human)

PMID 22423966

Rubicon positively regulates the NADPH oxidase complex to induce phagosomal trafficking of p22phox-gp91phox (which are subunits of NADPH oxidase), and the induction of reactive oxygen species and inflammatory cytokines. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 22423967

[Homo sapiens] RUBICON is a physiological feedback inhibitor of pattern recognition receptor signalling, preventing unbalanced proinflammatory responses.

PMID 22423966

[Homo sapiens] RUBICON positively regulates the NADPH oxidase complex to induce phagosomal trafficking of p22phox-gp91phox (which are subunits of NADPH oxidase), and the induction of reactive oxygen species and inflammatory cytokines.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145016:
The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:32821703-32877766

Strand

Reverse strand

Band

Transcripts

ENSMUST00000089684	ENSMUSP00000087114
ENSMUST00000040986	ENSMUSP00000048811
ENSMUST00000115105	ENSMUSP00000110757
ENSMUST00000119810	ENSMUSP00000113087
ENSMUST00000140229
ENSMUST00000135480
ENSMUST00000152920
ENSMUST00000153556
ENSMUST00000149621

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006897	endocytosis
GO:0006914	autophagy
GO:0010507	negative regulation of autophagy
GO:0045087	innate immune response (InnateDB)
GO:0045806	negative regulation of endocytosis

Cellular Component

GO:0005764	lysosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005794	Golgi apparatus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000145016

View Gene Order

ENSBTAG00000001890

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.327319 Mm.402903

RefSeq

NM_001200038 NM_172615

OMIM

CCDS

CCDS28124 CCDS49832

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas