Version 5.4
Mus musculus Gene: Foxd4
Summary
InnateDB Gene IDBG-154824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Foxd4
Gene Name forkhead box D4
Synonyms Fkh2; FREAC5
Species Mus musculus
Ensembl Gene ENSMUSG00000051490
Encoded Proteins
IDBP-154826
forkhead box D4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184492:
This gene is a member of the forkhead/winged-helix (FOX) family of transcription factors with highly conserved FOX DNA-binding domains. Members of the FOX family of transcription factors are regulators of embryogenesis and may play a role in human cancer. This gene lies in a region of chromosome 2 that surrounds the site where two ancestral chromosomes fused to form human chromosome 2. This region is duplicated elsewhere in the human genome, primarily in subtelomeric and pericentromeric locations, thus mutiple copies of this gene have been found. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:24898965-24901309
Strand Reverse strand
Band B
Transcripts
ENSMUST00000058600 ENSMUSP00000058575
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001755 neural crest cell migration
GO:0001822 kidney development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007389 pattern specification process
GO:0007422 peripheral nervous system development
GO:0030318 melanocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048484 enteric nervous system development
GO:0048485 sympathetic nervous system development
GO:0048846 axon extension involved in axon guidance
GO:0048937 lateral line nerve glial cell development
GO:0050935 iridophore differentiation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051216 cartilage development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000184492
View Gene Order
ENSBTAG00000033122
Not yet available
Cross-References
SwissProt Q60688
TrEMBL
UniProt Splice Variant
Entrez Gene 14237
UniGene Mm.377080
RefSeq NM_008022
OMIM
CCDS CCDS29715
HPRD
IMGT
MGI ID MGI:1347467
MGI Symbol Foxd4
EMBL BC138432 BC138434 X71940 X86368
GenPept AAI38433 AAI38435 CAA50742 CAA60128
RNA Seq Atlas 14237

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca