Version 5.4
Mus musculus Gene: Pmaip1
Summary
InnateDB Gene IDBG-155006.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pmaip1
Gene Name phorbol-12-myristate-13-acetate-induced protein 1
Synonyms Noxa
Species Mus musculus
Ensembl Gene ENSMUSG00000024521
Encoded Proteins
IDBP-155008
phorbol-12-myristate-13-acetate-induced protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21698224
Pmaip1 is induced by the RIG-I/MDA5 axis during viral infection and activates apoptosis in macrophages, dendritic cells and primary lymphocytes.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 18:66458604-66465550
Strand Forward strand
Band E1
Transcripts
ENSMUST00000025399 ENSMUSP00000025399
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 5 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411 response to UV
GO:0010165 response to X-ray
GO:0010498 proteasomal protein catabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0010917 negative regulation of mitochondrial membrane potential
GO:0032461 positive regulation of protein oligomerization
GO:0042149 cellular response to glucose starvation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043331 response to dsRNA
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048147 negative regulation of fibroblast proliferation
GO:0051607 defense response to virus
GO:0071456 cellular response to hypoxia
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072593 reactive oxygen species metabolic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_223399
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
REACT_199272
Activation of NOXA and translocation to mitochondria pathway
REACT_212161
Activation of BH3-only proteins pathway
REACT_204001
Intrinsic Pathway for Apoptosis pathway
KEGG
mmu04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9JM54
TrEMBL
UniProt Splice Variant
Entrez Gene 58801
UniGene Mm.271878
RefSeq NM_021451
OMIM
CCDS CCDS29315
HPRD
IMGT
MGI ID MGI:1930146
MGI Symbol Pmaip1
EMBL AB041230 AK043856 AK088556 AK143990 AK169914 BC050821
GenPept AAH50821 BAA95781 BAC31682 BAC40421 BAE25650 BAE41454
RNA Seq Atlas 58801

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca