InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mc4r

Summary

InnateDB Gene

IDBG-155030.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mc4r

Gene Name

melanocortin 4 receptor

Synonyms

Mc4-r

Species

Mus musculus

Ensembl Gene

ENSMUSG00000047259

Encoded Proteins

IDBP-155032

melanocortin 4 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased cholesterol levels and insulin resistance. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:66857715-66860472

Strand

Reverse strand

Band

Transcripts

ENSMUST00000057942

ENSMUSP00000054776

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0004980	melanocyte-stimulating hormone receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0031625	ubiquitin protein ligase binding
GO:0042923	neuropeptide binding

Biological Process

GO:0002024	diet induced thermogenesis
GO:0006112	energy reserve metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007631	feeding behavior
GO:0019222	regulation of metabolic process
GO:0030073	insulin secretion
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032868	response to insulin
GO:0045780	positive regulation of bone resorption
GO:0060259	regulation of feeding behavior
GO:2000252	negative regulation of feeding behavior
GO:2000821	regulation of grooming behavior