Version 5.4
Mus musculus Gene: Aga
Summary
InnateDB Gene IDBG-155091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aga
Gene Name aspartylglucosaminidase
Synonyms AW060726
Species Mus musculus
Ensembl Gene ENSMUSG00000031521
Encoded Proteins
IDBP-155093
aspartylglucosaminidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000038002:
Aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:53511702-53523421
Strand Forward strand
Band B1.3
Transcripts
ENSMUST00000033920 ENSMUSP00000033920
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003948 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
GO:0008233 peptidase activity
GO:0016787 hydrolase activity
GO:0043621 protein self-association
Biological Process
GO:0006508 proteolysis
GO:0006517 protein deglycosylation
GO:0051604 protein maturation
Cellular Component
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000038002
View Gene Order
ENSBTAG00000017085
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00511
Other glycan degradation pathway
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00511
Other glycan degradation pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt Q64191
TrEMBL A2RSS6 B7ZNK6
UniProt Splice Variant
Entrez Gene 11593
UniGene
RefSeq NM_001005847 NM_001205054
OMIM
CCDS CCDS22304
HPRD
IMGT
MGI ID MGI:104873
MGI Symbol Aga
EMBL BC132227 BC132229 BC145297 CH466554 S81393
GenPept AAB36101 AAI32228 AAI32230 AAI45298 EDL35636
RNA Seq Atlas 11593

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca