InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnip2

Summary

InnateDB Gene

IDBG-155271.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnip2

Gene Name

TNFAIP3 interacting protein 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059866

Encoded Proteins

IDBP-155273

TNFAIP3 interacting protein 2

IDBP-155275

TNFAIP3 interacting protein 2

IDBP-251951

TNFAIP3 interacting protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168884:
TNIP2 binds to the C-terminal zinc finger domain of A20 (TNFAIP3; MIM 191163) and is involved in activation of the ERK (see MAPK3; MIM 601795) MAP kinase pathway in various cell types (Van Huffel et al., 2001 [PubMed 11390377]; Papoutsopoulou et al., 2006 [PubMed 16633345]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:34496087-34513997

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030991	ENSMUSP00000030991
ENSMUST00000087737	ENSMUSP00000085030
ENSMUST00000114359	ENSMUSP00000109999
ENSMUST00000144791
ENSMUST00000143072
ENSMUST00000137555
ENSMUST00000159102

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0023035	CD40 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0043032	positive regulation of macrophage activation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050821	protein stabilization
GO:0050871	positive regulation of B cell activation
GO:0070498	interleukin-1-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000168884

View Gene Order

ENSBTAG00000015126

Not yet available

Pathways

NETPATH

REACTOME

REACT_233584

Cytokine Signaling in Immune system pathway

REACT_230745

Immune System pathway

REACT_261687

Signaling by Interleukins pathway

REACT_224208

Interleukin-1 signaling pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

REACT_22442

Interleukin-1 signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_6900

Immune System pathway

REACT_22232

Signaling by Interleukins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.28615

RefSeq

NM_139064

OMIM

CCDS

CCDS19214

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas