Version 5.4
Mus musculus Gene: Scx
Summary
InnateDB Gene IDBG-155294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scx
Gene Name scleraxis
Synonyms BB114693; Bhlha41; Scl
Species Mus musculus
Ensembl Gene ENSMUSG00000034161
Encoded Proteins
IDBP-155296
scleraxis
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation. The encoded protein is expressed during embryonic development of tendons and ligaments. The gene product regulates collagen type I gene expression in cardiac fibroblasts and myofibroblasts, and it may play a role in myocardial remodeling. The protein is expressed in the scar area of the adult heart following myocardial infarction. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:76457438-76459468
Strand Forward strand
Band D3
Transcripts
ENSMUST00000043089 ENSMUSP00000043668
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0001707 mesoderm formation
GO:0001894 tissue homeostasis
GO:0001958 endochondral ossification
GO:0002062 chondrocyte differentiation
GO:0003179 heart valve morphogenesis
GO:0003188 heart valve formation
GO:0006351 transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0030154 cell differentiation
GO:0030199 collagen fibril organization
GO:0030509 BMP signaling pathway
GO:0032967 positive regulation of collagen biosynthetic process
GO:0035914 skeletal muscle cell differentiation
GO:0035989 tendon development
GO:0035990 tendon cell differentiation
GO:0035992 tendon formation
GO:0035993 deltoid tuberosity development
GO:0043066 negative regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048706 embryonic skeletal system development
GO:0051216 cartilage development
GO:0060008 Sertoli cell differentiation
GO:0060325 face morphogenesis
GO:0061035 regulation of cartilage development
GO:0061036 positive regulation of cartilage development
GO:0061056 sclerotome development
GO:0071260 cellular response to mechanical stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071773 cellular response to BMP stimulus
GO:2000543 positive regulation of gastrulation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000009816
Not yet available
Cross-References
SwissProt Q64124
TrEMBL Q53ZC3
UniProt Splice Variant
Entrez Gene 20289
UniGene Mm.322821
RefSeq NM_198885
OMIM
CCDS CCDS27571
HPRD
IMGT
MGI ID MGI:102934
MGI Symbol Scx
EMBL AY338482 CH466545 S78079
GenPept AAB34266 AAR01197 EDL29568
RNA Seq Atlas 20289

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca