InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp6v1g1

Summary

InnateDB Gene

IDBG-155483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v1g1

Gene Name

ATPase, H+ transporting, lysosomal V1 subunit G1

Synonyms

1810024D14Rik; AA960677; Atp6g1; ATP6J; VAG1; Vma10

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039105

Encoded Proteins

IDBP-155485

ATPase, H+ transporting, lysosomal V1 subunit G1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136888:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:63544772-63550750

Strand

Forward strand

Band

Transcripts

ENSMUST00000035301

ENSMUSP00000048770

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887	ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0015992	proton transport
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005622	intracellular
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex