InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cd8a

Summary

InnateDB Gene

IDBG-155582.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd8a

Gene Name

CD8 antigen, alpha chain

Synonyms

BB154331; Ly-2; Ly-35; Ly-B; Lyt-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053977

Encoded Proteins

IDBP-155584

CD8 antigen, alpha chain

IDBP-619795

CD8 antigen, alpha chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21867928

Cd8a-positive dendritic cells play a critical role in cross-presentation of antigens during intracellular pathogen infections, specifically by activating an innate immune response through Il12 production.

InnateDB Annotation from Orthologs

Summary

PMID 21867928

[Homo sapiens] CD8A-positive dendritic cells play a critical role in cross-presentation of antigens during intracellular pathogen infections, specifically by activating an innate immune response through IL12 production. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153563:
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:71373427-71379171

Strand

Forward strand

Band

Transcripts

ENSMUST00000066747	ENSMUSP00000068123
ENSMUST00000172321	ENSMUSP00000131873

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002456	T cell mediated immunity
GO:0007166	cell surface receptor signaling pathway
GO:0042110	T cell activation
GO:0045065	cytotoxic T cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0050850	positive regulation of calcium-mediated signaling
GO:0051607	defense response to virus